RapamycinFungusV1, Main, Exploration, bibRecord, 000230

Spatially distinct pools of TORC1 balance protein homeostasis.

Identifieur interne : 000230 ( Main/Exploration ); précédent : 000229; suivant : 000231

Spatially distinct pools of TORC1 balance protein homeostasis.

Auteurs : Vikramjit Lahiri [États-Unis] ; Daniel J. Klionsky [États-Unis]

Source :

Autophagy [ 1554-8635 ] ; 2019.

RBID : pubmed:30696339

Descripteurs français

KwdFr :
- Autophagie (MeSH), Complexe-1 cible mécanistique de la rapamycine (MeSH), Homéostasie protéique (MeSH), Protéines de Saccharomyces cerevisiae (MeSH), Saccharomyces cerevisiae (MeSH).
MESH :
- Autophagie, Complexe-1 cible mécanistique de la rapamycine, Homéostasie protéique, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.

English descriptors

KwdEn :
- Autophagy (MeSH), Mechanistic Target of Rapamycin Complex 1 (MeSH), Proteostasis (MeSH), Saccharomyces cerevisiae (MeSH), Saccharomyces cerevisiae Proteins (MeSH).
MESH :
- chemical : Mechanistic Target of Rapamycin Complex 1, Saccharomyces cerevisiae Proteins.
- Autophagy, Proteostasis, Saccharomyces cerevisiae.

Abstract

In eukaryotes, TORC1/MTORC1 is a critical regulator of growth and proliferation. In response to nutrient abundance TORC1/MTORC1 favors anabolic processes and retards degradative ones. In S. cerevisiae, TORC1 is conventionally known to localize on the vacuolar membrane. In the course of their recent investigations, Hatakeyama et al. discovered a novel second site of TORC1 localization- the prevacuolar endosome. Their article, highlighted here, discusses the mechanism of TORC1 localization to the prevacuolar endosome and highlights a hitherto unappreciated mechanism by which 2 spatially separated pools of TORC1 execute the distinct functions of promoting anabolism and inhibiting degradation.

DOI: 10.1080/15548627.2019.1575162
PubMed: 30696339
PubMed Central: PMC6526836

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
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<term>Complexe-1 cible mécanistique de la rapamycine</term>
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<front><div type="abstract" xml:lang="en">In eukaryotes, TORC1/MTORC1 is a critical regulator of growth and proliferation. In response to nutrient abundance TORC1/MTORC1 favors anabolic processes and retards degradative ones. In S. cerevisiae, TORC1 is conventionally known to localize on the vacuolar membrane. In the course of their recent investigations, Hatakeyama et al. discovered a novel second site of TORC1 localization- the prevacuolar endosome. Their article, highlighted here, discusses the mechanism of TORC1 localization to the prevacuolar endosome and highlights a hitherto unappreciated mechanism by which 2 spatially separated pools of TORC1 execute the distinct functions of promoting anabolism and inhibiting degradation.</div>
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	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Spatially distinct pools of TORC1 balance protein homeostasis.

Spatially distinct pools of TORC1 balance protein homeostasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki